Dry eye disease management is evolving beyond symptom suppressiontoward therapies that restore ocular surface health through regenerativeapproaches. Emerging biologics such as exosomes, amniotic membrane therapiesand nerve growth factor (NGF)-based treatments, including those currently inthe pipeline, aim to promote cellular repair, support corneal nerveregeneration and modulate inflammation. This course reviews the mechanisms andcurrent evidence behind these regenerative therapies and discusses how they canbe integrated into modern ocular surface disease management, particularly inpatients with chronic or treatment-refractory dry eye.

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